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Alfatradiol

Also known as: Ell-Cranell, 17α-estradiol

Limited EvidencePharmaceuticalAndrogenic Alopecia

Topical estrogen stereoisomer that locally inhibits 5-alpha reductase without systemic hormonal effects.

Regrowth Potential20%
Long-Term Viability55%

Mechanism of Action

Alfatradiol (17α-estradiol) is a weak estrogen stereoisomer that inhibits 5-alpha reductase locally in the scalp. Unlike 17β-estradiol, it has minimal systemic estrogenic activity, making it suitable for both sexes. It reduces local DHT conversion without affecting serum hormone levels.

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