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Clascoterone

Also known as: Breezula, CB-03-01, Winlevi (acne formulation)

Limited EvidencePharmaceuticalAndrogenic Alopecia

First-in-class topical androgen receptor antagonist; FDA-approved for acne, in trials for AGA.

Regrowth Potential35%
Long-Term Viability60%

Mechanism of Action

Clascoterone is a topical androgen receptor (AR) inhibitor that competes with DHT for AR binding directly at the follicle. Unlike systemic anti-androgens, it is metabolized locally to cortexolone, minimizing systemic exposure. It blocks androgen signaling at the receptor level rather than reducing DHT production.

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